Publications
2021：
61. Shuai Yang; Yanghui Zhang*;
" Synthesis of 9-Fluorenylidenes via Pd-Catalyzed C-H Vinylation with Vinyl Bromides "
Org. Lett. 2021, 23, 7746. < Link>
60. Zechen Wu; Cang Cheng; Yanghui Zhang*;
" Transition Metal-Catalyzed Reactions of C-H Bonds with Carbon Monoxide"
有机化学, 2021, 41, 2155. < Link>
59. Cang Cheng; Qiongqiong Zhu; Yanghui Zhang*;
" Intermolecular C-H Silylation through Cascade Carbopalladation and vinylic to aryl 1,4-palladium migration"
Chem. Commun. 2021, 57, 9700. < Link>
58. Cang Cheng; Yanghui Zhang*;
" Palladium-Catalyzed anti-Carbosilylation of Alkynes to Access Isoquinolinone-Containing Exocyclic Vinylsilanes"
Org. Lett. 2021, 23, 5772. < Link>
57. Zhuo Wu+; Zechen Wu+; Xueliang Sun; Weixin Qi; Zhengyang Zhang; Yanghui Zhang*; (+equal contribution)
" Palladium-Catalyzed Intramolecular Cross-Coupling of Unactivated C(sp3)-H and C(sp2)-H Bonds"
Org. Lett. 2021, 23, 7161. < Link>
56. Zhuo Wu; Hang Jiang; Yanghui Zhang*;
" Pd-catalyzed cross-electrophile coupling/C-H alkylation reaction enabled by a mediator generated via C(sp3)-H activation"
Chem. Sci. 2021, 12, 8531.< Link>
55. Bin Wan; Yanghui Zhang*;
" Synthesis of unsymmetrically substituted tetraphenylenes through palladium-catalyzed C(sp2)-H activation"
Synthesis. 2021, 53, 3299.< Link>
54. Zhuo Wu; Feng Wei; Bin Wan; Yanghui Zhang*;
" Pd-catalyzed ipso,meta-dimethylation of ortho-substituted iodoarenes via a base-controlled C-H activation cascade with dimethyl carbonate as the methyl source"
J. Am. Chem. Soc. 2021, 143, 4524. < Link>
53. Cang Cheng; Xiang Zuo; Dongdong Tu; Bin Wan; Yanghui Zhang*;
" Palladium-catalyzed diastereoselective cross-coupling of two aryl halides via C-H activation: synthesis of chiral eight-membered nitrogen heterocycles"
Chem. Commun. 2021, 57, 2939. < Link>
52. Bin Wan; Zhuoer Lu; Zhuo Wu; Cang Cheng; Yanghui Zhang*;
"Diastereoselective construction of eight-membered carbocycles through palladium-catalyzed C(sp3)-H activation"
Org. Lett. 2021, 23, 1269. < Link>
51. Cang Cheng; Dongdong Tu; Xiang Zuo; Zechen Wu; Bin Wan; Yanghui Zhang*;
"Palladium-catalyzed dual coupling reaction of 2-iodobiphenyls with ortho-bromoanilines through C-H activation: an approach for the synthesis of tribenzo[b,d,f]azepines"
Org. Lett. 2021, 23, 1239. < Link>
50. Xiaoming Ji; Guangfa Shi; Yanghui Zhang*;
"Progress of trifluoromethylation using trifluoroacetic acid and its derivatives as CF3-sources"
有机化学, 2019, 39, 929. < Link>
2020：
49. Yichao Gu; Xueliang Sun; Bin Wan; Zhuoer Lu; Yanghui Zhang*;
"C(sp3)-H activation-enabled cross-coupling of two aryl halides: an approach to 9,10-dihydrophenanthrenes"
Chem. Commun. 2020, 56, 10942. < Link>
48. Xiaoming Ji; Feng Wei; Bin Wan; Cang Cheng; Yanghui Zhang*;
"Palladium-catalyzed intermolecular C-H silylation initiated by aminopalladation"
Chem. Commun. 2020, 56, 7801. < Link>
47. Cang cheng; Xiang Zuo; Dongdong Tu; Bin Wan; Yanghui Zhang*;
"Synthesis of 3,4-fused tricyclic indoles through cascade carbopalladation and C-H amination: development and total synthesis of rucaparib"
Org. Lett. 2020, 22, 4985. < Link>
46. Xiaoming Ji; Yichao Gu; Cang Cheng; Zhuo Wu; Yanghui Zhang*;
"Palladium-catalyzed three-component reactions for synthesis of norborene-fused indanes"
Adv. Synth. Catal. 2020, 362, 1496. < Link>
2019：
45. Cang Cheng; Bin Wan; Bo Zhou; Yichao Gu; Yanghui Zhang*;
"Enantioselective synthesis of quaternary 3,4-dihydroisoquinolinones via heck carbonylation reactions: development and application to the synthesis of minalresat analogues"
Chem. Sci., 2019, 10, 9853. < Link>
44. Xueliang Sun; Zhuo Wu; Weixin Qi; Xiaoming Ji; Cang Cheng; Yanghui Zhang*;
"Synthesis of indolines by palladium-catalyed intermolecular amination of unactivated C(sp3)-H bond"
Org. Lett. 2019, 21, 6508. < Link>
43. Ding Ma; Xiaoming Ji; Zhuo Wu; Cang Cheng; Bo Zhou; Yanghui Zhang*;
"Synthesis of benzimidazoles through palladium-catalyed amination of 2-iodobenzimines with diaziridinone"
Adv. Synth. Catal. 2019, 361, 739. < Link>
42. Bo Zhou; Ailan Lu; Yanghui Zhang*;
"Pd-catalyzed C-H silylation reactions with disilanes"
Synlett. 2019, 30, 685. < Link>
2018：
41. Bo Zhou; Zhuo Wu; Weixin Qi; Xueliang Sun; Yanghui Zhang*;
"Synthesis of benzofulvenes through palladium-catalyzed sequential three-component reactions"
Adv. Synth. Catal. 2018, 360, 4480. < Link>
▪ Selected as a very important publication (VIP).
40. Bo Zhou; Zhuo Wu; Ding Ma; Xiaoming Ji; Yanghui Zhang*;
"Synthesis of indoles through palladium-catalyzed three-component reaction of aryl iodides, alkynes, and diaziridione"
Org. Lett. 2018, 20, 6440. < Link>
39. Bo Zhou; Ailan Lu; Changdong Shao; Xinda Liang; Yanghui Zhang*;
"Palladium-catalyzed sequential three-component reaction to access vinylsilanes"
Chem. Commun. 2018, 54, 10598. < Link>
38. Xiaotian Ma; Ailan Lu; Xiaoming Ji; Guangfa Shi; Yanghui Zhang*;
"Disilylation of palladacycles that were generated through the C-H activation of aryl halides"
Asian J. Org. Chem. 2018, 7, 1403. < Link>
▪ Invited paper in special issue: C-H activation.
37. Guangfa Shi; Changdong Shao; Xiaotian Ma; Yichao Gu; Yanghui Zhang*;
"Pd(II)-catalyzed Catellaini-type Domino reaction utilizing arylboronic acids as substrates"
ACS Catal. 2018, 8, 3775. < Link>
36. Ailan Lu+; Xiaoming Ji+; Bo Zhou; Zhuo Wu; Yanghui Zhang*; (+equal contribution)
"Palladium-catalyzed C-H silylation through palladacycles generated from aryl halides"
Angew. Chem. Int. Ed. 2018, 57, 3233. < Link>
35. Changdong Shao; Bo Zhou; Zhuo Wu; Xiaoming Ji; Yanghui Zhang*;
"Synthesis of carbazoles from 2-iodobiphenyls by palladium-catalyzed C-H activation and amination with diaziridinone"
Adv. Synth. Catal. 2018, 360, 887. < Link>
34. Ding Ma; Guangfa Shi; Zhuo Wu; Xiaoming Ji; Yanghui Zhang*;
"Synthesis of 9,9-disubstituted fluorenes from 2-iodobiphenyls and α-diazoesters under palladium catalyst"
J. Org. Chem. 2018, 83, 1065. < Link>
2017：
33. Changdong Shao; Zhuo Wu; Xiaoming Ji; Bo Zhou; Yanghui Zhang*;
"An approach to spirooxindoles via palladium-catalyzed remote C-H actvation and dual alkylation with CH2Br2"
Chem. Commun. 2017, 53, 10429. < Link>
32. Zhuo Wu; Ding Ma; Bo Zhou; Xiaoming Ji; Xiaotian Ma; Xiaoling Wang; Yanghui Zhang*;
"Palladium-catalyzed alkylation with alkyl halides by C( sp3)-H activation"
Angew. Chem. Int. Ed. 2017, 56, 12288. < Link>
31. Xiaoling Wang; Xiaoming Ji; Changdong Shao; Yu Zhang; Yanghui Zhang*;
"Palladium-catalyzed C-H alkylation of 2-phenylpyridines with alkyl iodides"
Org. Biomol. Chem. 2017, 15, 5616. < Link>
30. Changdong Shao; Ailan Lu; Xiaoling Wang; Bo Zhou; Xiaohong Guan; Yanghui Zhang*;
"Oxalic acid as the in situ carbon monoxide generator in palladium-catalyzed hydroxycarbonylation of arylhalides"
Org. Biomol. Chem. 2017, 15, 5033. < Link>
2016：
29. Changdong Shao; Guangfa Shi; Yanghui Zhang*;
" Easy access to difluoromethylene-containing arene analogues through palladium-catalyzed C–H olefination"
Eur. J. Org. Chem. 2016, 5529. < Link>
28. Shulei Pan; Hang Jiang; Yu Zhang; Dushen Chen; Yanghui Zhang*;
" Synthesis of triphenylenes starting from 2-Iodobiphenyls and Iodobenzenes via palladium-catalyzed dual C-H activation and double C-C bond formation"
Org. Lett. 2016, 18, 5192. < Link>
27. Shulei Pan; Hang Jiang; Yanghui Zhang*; Yu Zhang; Dushen Chen;
"Synthesis of 2-substituted tetraphenylenes via transition-metal-catalyzed derivatization of tetraphenylene"
Beilstein J. Org. Chem. 2016, 12, 1302. < Link>
26. Guangfa Shi; Dushen Chen; Hang Jiang; Yu Zhang; Yanghui Zhang*
"Synthesis of Fluorenes Starting from 2-Iodobiphenyls and CH2Br2 through Palladium-Catalyzed Dual C-C Bond Formation"
Org. Lett. 2016, 18, 2958. < Link>
25. Shulei Pan; Hang Jiang; Yu Zhang; Dushen Chen; Yanghui Zhang*
"Synthesis of Unsymmetrically Disubstituted Tetraphenylenes via Carbonyl-Directed C-H Functionalization"
Synlett. 2016, 27, 1997. < Link>
24. Yu Zhang; Hang Jiang; Dushen Chen; Yanghui Zhang*
"Amino acid-promoted C-H alkylation with alkylboronic acids using a removable directing group"
Org. Biomol. Chem. 2016, 14, 4585 < Link>
23. Hang Jiang; Yu Zhang; Dushen Chen; Bo Zhou; Yanghui Zhang*
"An approach to tetraphenylenes via Pd-catalyzed C-H functionalization"
Org. Lett. 2016, 18, 2032 < Link>
22. Dushen Chen; Guangfa Shi; Hang Jiang; Yu Zhang; Yanghui Zhang*
"Sequential difunctionalization of 2-Iodobiphenyls by exploiting the reactivities of a palladacycle and an acyclic arylpalladium species"
Org. Lett. 2016, 18, 2130 < Link>
21. Shulei Pan; Bo Zhou; Yanghui Zhang*; Changdong Shao; Guangfa Shi
"A versatile approach for the synthesis of para-substituted arenes via palladium-catalyzed C-H functionalization and protodecarboxylation of benzoic acids"
Synlett. 2016, 27, 277 < Link>
2015：
20. Hongqiang Liu; Jun Liu; Changdong Shao; Jingxun Yu; Yanghui Zhang*
"Copper-catalyzed amide bond formation from formamides and carboxylic acids"
Chinese Chem. Lett. 2015, 26, 11 < Link>
19. Changdong Shao; Guangfa Shi; Yanghui Zhang*; Shulei Pan; Xiaohong Guan
"Palladium-catalyzed C–H ethoxycarbonyldifluoromethylation of electron-rich heteroarenes"
Org. Lett. 2015, 17, 2652 < Link>
18. Jingxun Yu; Jun Liu; Guangfa Shi; Changdong Shao; Yanghui Zhang*
"Ligand-promoted oxidative cross-coupling of aryl boronic acids and aryl silanes by palladium catalysis"
Angew. Chem. Int. Ed. 2015, 54, 4079 < Link>
▪ Reported in C&E News 2015, February 16, 7;
▪ VIP article.
17. Guangfa Shi; Changdong Shao; Shulei Pan; Jingxun Yu; Yanghui Zhang*
"Silver-catalyzed C–H trifluoromethylation of arenes using trifluoroacetic acid as the trifluoromethylating reagent"
Org. Lett. 2015, 17, 38. < Link>
2014：
16. Guangfa Shi; Yanghui Zhang*
"Carboxylate-directed C-H functionalization"
Adv. Synth. Catal. 2014, 356, 1419. < Link>
15. Yuyu, Jiang; Shulei Pan; Yanghui Zhang*; Jingxun Yu; Hongqiang Liu
"Copper-catalyzed decarboxylative methylation of aromatic carboxylic acids with PhI(OAc)2"
Eur. J. Org. Chem. 2014, 2027. < Link>
14. Jun Liu; Changdong Shao; Yanghui Zhang*; Guangfa Shi; Shulei Pan
"Copper-catalyzed highly efficient ester formation from carboxylic acids/esters and formates"
Org. Biomol. Chem. 2014, 12, 2637. < Link>
2013：
13. Hongqiang Liu; Guangfa, Shi; Shulei, Pan; Yuyu, Jiang; Yanghui Zhang*
"Palladium-catalyzed benzylation of carboxylic acids with toluene via benzylic C-H activation"
Org. Lett. 2013, 15, 4098. < Link>
Graduate and Postdoctoral Research:
12. Huixiong Dai; Antonia F. Stepan; Mark S. Plummer; Yanghui Zhang; Jinquan Yu
"Divergent C–H functionalizations directed by sufonamide pharmacophores: late-stage diversification as a tool for drug discovery"
J. Am. Chem. Soc. 2011, 133, 7222.
▪ One of the Top 10 most read JACS articles in April 2011.
11. Bingfeng Shi; Yanghui Zhang; Jonathan, Lam; Donghui, Wang; Jinquan Yu
"Pd(II)-catalyzed enantioselective C-H olefination of diphenylacetic acids"
J. Am. Chem. Soc. 2010, 132, 460.
▪ One of the Top 20 most read JACS articles in December 2009.
10. Yanghui Zhang; Jinquan Yu
"Pd(II)-catalyzed hydroxylation of arenes with 1 atm O2 or air"
J. Am. Chem. Soc. 2009, 131, 14654.
▪ Reported in C&E News 2009, October 12, 44;
▪ Featured in SynFacts;
▪ Featured online at the Organic Chemistry Portal;
▪ One of the Top 20 most read JACS articles in November 2009.
9. Yanghui Zhang; Bingfeng Shi; Jinquan Yu
"Pd(II)-catalyzed ortho-alkylation of benzoic acids with alkyl halides"
Angew. Chem. Int. Ed. 2009, 48, 6097.
▪ Selected as a hot paper.
8. Yanghui Zhang; Bingfeng Shi; Jinquan Yu
"Pd(II)-catalyzed olefination of electron-deficient arenes using 2,6-dialkyl pyridine ligands"
J. Am. Chem. Soc. 2009, 131, 5072.
▪ Featured in Science 2009, 324, 15;
▪ Reported in C&E News. 2009, March 23, 7;
▪ Featured in ChemCatChem. 2009, 1, 69;
▪ Featured in SynFacts 2009, 7, 0785;
▪ Featured in Angew. Chem. Int. Ed. 2009, 48, 7126.
7. Bingfeng Shi, Nathan Maugel, Yanghui Zhang, Jinquan Yu
"Pd(II)-catalyzed enantioselective activation of sp2 and sp3 C−H bonds using mono-protected amino acids as chiral ligands"
Angew. Chem. Int. Ed. 2008, 47, 4882.
▪ Selected as a hot paper and featured on the front cover;
▪ Featured in Science 2008, 320, 1262;
▪ Reported in C&E News, 2008, June 9, 12;
▪ Featured in Angew. Chem. Int. Ed. 2010, 49, 5826.
6. Jidnyasa Gaekwad; Yanghui Zhang; Wei Zhang; Jaxk Reeves; Margreet A. Wolfert; Geert-Jan Boons
"Differential induction of innate immune responses by synthetic Lipid A derivatives"
J. Bio. Chem. 2010, 285, 29375.
5. Yanghui Zhang; Jidnyasa Gaekwad; Margreet A. Wolfert; Geert-Jan Boons
"Synthetic tetra-acylated derivatives of lipid A from Porphyromonas gingivalis are antagonists of human TLR4"
Org. Biomol. Chem. 2008, 6, 3371.
4. Yanghui Zhang; Jidnyasa Gaekwad; Margreet A. Wolfert; Geert-Jan Boons
"Innate immune responses of synthetic lipid A derivatives of Neisseria meningitidis"
Chem. Eur. J. 2008, 14, 558.
3. Yanghui Zhang; Jidnyasa Gaekwad; Margreet A. Wolfert; Geert-Jan Boons
"Modulation of innate immune responses with synthetic lipid A derivatives"
J. Am. Chem. Soc. 2007, 129, 5200.
2. Yanghui Zhang; Margreet A. Wolfert; Geert-Jan Boons
"The influence of the long chain fatty acid on the antagonistic activities of Rhizobium sin-1 lipid A"
Bioorg. Med. Chem. 2007, 15, 4800.
1. Hyi-Seung Lee; Margreet A. Wolfert; Yanghui Zhang; Geert-Jan Boons
"The 2-amino-gluconate isomer of Rhizobium sin-1 lipid A can antagonize TNF-α production induced by enteric LPS"
Chembiochem 2006, 7, 140.
Book Chapter：
Yanghui Zhang; Guangfa Shi; Jin-Quan Yu；
"Carbon–Carbon σ-Bond Formation via C–H Bond Functionalization in Comprehensive Organic Synthesis" , 2nd Edition
Vol. 3 (Eds.: G. Molander, P. Knochel), Elsevier: Oxford, 2014, pp 1101-1209.